Essential immunology

Fülszöveg

ESSENTiAL IMMUN0L0GÍ6IXTH EDITION
This revised reprint of the sixth edition contains new diagrams and additions to the text, as well as expanded coverage of AIDS. The book incorporates the following features:
• Radically reshaped and updated, reflecting the anthor's changed perceptions since the first edition in 1970
• Emphasis placed on both the role of innate immunity in providing basic mechanisms of defence against infection and on the manner in which lymphocyte-mediated adap-tive responses enormously enhance innate mechanisms
• Single chapter discussion of the diversity of molecules concerned in antigén recognition - immunoglobulins, T-cell receptors and the major histocompatibility complex
• T- and B-cell activities and activation taken in parallel, with expanded section on what the T-cell 'sees'
• Recent diseoveries of new cytokines deseribed and immunological networks extended to include neurological and endocrine systems
• B- and T-cell ontogeny treated in depth... Tovább

Fülszöveg

ESSENTiAL IMMUN0L0GÍ6IXTH EDITION
This revised reprint of the sixth edition contains new diagrams and additions to the text, as well as expanded coverage of AIDS. The book incorporates the following features:
• Radically reshaped and updated, reflecting the anthor's changed perceptions since the first edition in 1970
• Emphasis placed on both the role of innate immunity in providing basic mechanisms of defence against infection and on the manner in which lymphocyte-mediated adap-tive responses enormously enhance innate mechanisms
• Single chapter discussion of the diversity of molecules concerned in antigén recognition - immunoglobulins, T-cell receptors and the major histocompatibility complex
• T- and B-cell activities and activation taken in parallel, with expanded section on what the T-cell 'sees'
• Recent diseoveries of new cytokines deseribed and immunological networks extended to include neurological and endocrine systems
• B- and T-cell ontogeny treated in depth alongside: a large new section on lymphoproliferative disorders arising as unregulated development of lymphoid cells
• Immunity to infection viewed as unremitting warfare between host and microbe
• More prominence given to the acquired immunodeficiency syndrome (AIDS)
• Newer advances in IgE receptors, biochemistry of mast cell activation and importance of late reactions in allergy all included
THE AUTHOR
Professor Roitt was born in 1927 and educated at King Edward's School, Birmingham, and Balliol College, Oxford. Soon after taking up research at the Middlesex Hospitál Medical School in 1953, he began work with Péter Campbell on experimentál tumour autoimmunity. In 1956, together with Deborah Doniach, they made the classic diseovery of thyroglobulin autoantibodies in Hashimoto's thyroiditis which helped to open the whole
• Growing importance of cyclosporin A in transplanta-tion underlined
• New developments in cancer immunotherapy based on biological response modifiers deseribed
• Pathogenesis of rheumatoid arthritis fully documented focusing on glycosylation defects in IgC
The reader will appreciate the immediacy of style, the striking illustrations, the new colour plates and the two-colour formai of this greatly improved edition.
From the reviews of the sixth edition
'1 heartily recommend this readable, value-for-money, and visually appealing text to the undergraduate and the practitioner who wishes to be brought up to date on the subject.' Tlw Lancet
'The author, a well known immunologist, rightly states that this is a new book rather than new advances being fitted into the overall structure of the previous edition, and the preface, apart from delineating the changes made since 1984, is a useful deseription of recent advances in this subject. The book is comprehensive and covers, for example, basic facts such as innate and specific acquired immunity, molecules that recognise antigén and consequ-ences of antigén recognition, immunity to infection (in-cluding AIDS), hypersensitivity, transplantation and the autoimmune diseases.' British Medical Journal
Consultanl art editor: Mike Rubens
concept of a relationship between autoimmunity and humán disease. The work was extended to an intensive study of autoimmune phenomena in pernicious anaemia and primary biliary cirrhosis. This work was recognized by the award of the Van Meter prize of the American Goiter Association in 1957 and a Gairdner Foundation award in 1964.
Shortly after becoming Professor and Head of the newly created Department of Immunology at the Middlesex Hospitál Medical School (now University College and Middlesex School of Medicine), Roitt and his col-leagues began a series of experiments on rheumatoid arthritis which have greatly strengthened the hypothesis that the pathogenesis of joint destruction in this disease may be entirely attributable to IgG autosensitization. In 1969 he and his colleagues wrote a review of cellular immunology in which the abbreviations B and T lympho-cyte were first introduced.
Professor Roitt has been a member of the editorial boards of many journals, meetings secretary of the British Society for Immunology, chairman of the steering com-mittee of the WHO task force on immunological control of fertility and a member of the biological subeommittee of the British University Grants Committee. In 1983 he was elected a Fellow of The Royal Society. Vissza