Essential immunology

Fülszöveg

SIXTH EDITION
This edition has been more extensively revised than any since the book's original publication and incorporates the following features:
• Radically reshaped and updated, reflecting the author's changed perceptions since the first edition in 1970
• Emphasis placed on both the role of innate immunity in providing basic mechanisms of defence against infection and on the manner in which lymphocyte-mediated adaptive responses enormously enhance innate mechanisms
• Single chapter discussion of the diversity of molecules concerned in antigen recognition - immunoglobulins, T-cell receptors and the major histocompatibility complex
• T- and B-cell activities and activation taken in parallel, with expanded section on what the T-cell 'sees'
• Recent discoveries of new cytokines described and immunological networks extended to include neurological and endocrine systems
• B- and T-cell ontogeny treated in depth alongside a large new section on lymphoproliferative disorders... Tovább

Fülszöveg

SIXTH EDITION
This edition has been more extensively revised than any since the book's original publication and incorporates the following features:
• Radically reshaped and updated, reflecting the author's changed perceptions since the first edition in 1970
• Emphasis placed on both the role of innate immunity in providing basic mechanisms of defence against infection and on the manner in which lymphocyte-mediated adaptive responses enormously enhance innate mechanisms
• Single chapter discussion of the diversity of molecules concerned in antigen recognition - immunoglobulins, T-cell receptors and the major histocompatibility complex
• T- and B-cell activities and activation taken in parallel, with expanded section on what the T-cell 'sees'
• Recent discoveries of new cytokines described and immunological networks extended to include neurological and endocrine systems
• B- and T-cell ontogeny treated in depth alongside a large new section on lymphoproliferative disorders arising as unregulated development of lymphoid cells
• Immunity to infection viewed as unremitting warfare between host and microbe
• More prominence given to the acquired immunodeficiency syndrome (AIDS)
• Newer ad%'ances in IgE receptors, biochemistry of mast cell activation and importance of late reactions in allergy all included
• Growing importance of cyclosporin A in transplantation underlined
• New developments in cancer immunotherapy based on biological response modifiers described
• Pathogenesis of rheumatoid arthritis fully documented focusing on glycosylation defects in IgC
The reader will appreciate the immediacy of style, the striking illustrations, the new colour plates and the two-colour format of this greatly improved edition.
From the reviews of the fifth edition
'This fifth edition of Professor Roitt's uniquely successful book maintains the exceptional standards of the previous editions. . . . The book remains excellent value for money . . .' Imnninoiog]/.
'This book has always been an outstanding, readable basic text and the Fifth Edition will certainly be received with the same enthusiasm as its predecessors. The author and the publishers arc to be congratulated on their achievement.' fournal oflnnuunological Methods.
'This book has brought me up to date on monoclonal antibodies, interleukins, the major histocompatibility complex and many other topics of current and clinical interest and goes to join the first four editions on my bookshelf. The dust is not likely to gather on it there.' Chest.
Consultant art editor: Mike Rubens
THE AUTHOR
Professor Roitt was born in 1927 and educated at King Edward's School, Birmingham, and Balliol College, Oxford. Soon after taking up research at the Middlesex Hospital Medical School in 1953, he began work with Peter Campbell on experimental tumour autoimmunity. In 1956, together with Deborah Doniach, they made the classic discovery of Ihyroglobulin autoantibodies in Hashimoto's thyroiditis which helped to open the whole
concept of a relationship between autoimmunity and human disease. The work was extended to an intensive study of autoimmune phenomena in pernicious anaemia and primary biliary cirrhosis. This work was recognized by the award of the Van Meter prize of the American Goiter Association in 1957 and a Gairdner Foundation award in 1964.
Shortly after becoming Professor and Head of the newly created Department of Immunology at the Middlesex Hospital Medical School (now University College and Middlesex School of Medicine), Roitt and his colleagues began a series of experiments on rheumatoid arthritis which have greatly strengthened the hypothesis thai the pathogenesis of joint destruction in this disease may be entirely attributable to IgG autosensitization. In 1969 he and his colleagues wrote a review of cellular immunology in which the abbreviations B and T lymphocyte were first introduced.
Professor Roitt has been a member of the editorial boards of many journals, meetings secretary of Ihe British Society for Immunology, chairman of the steering committee of the WHO task force on immunological control of fertility and a member of the biological subcommittee of the British University Grants Committee. In 1983 he was elected a Fellow of The Royal Society. isfc Vissza