A Textbook of Drug Design and Development

Fülszöveg

A TEXTBOOK OF DRUG DESIGN AND DEVELOPMENT SECOND EDITION edited by
Povl Krogsgaard-Larsen, Tommy Liljefors and Ulf Madsen
The second edition of A Textbook of Drug Design and Development has been completely revised and updated. It covers the separate but interconnecting areas of chemistry and biology, maintaining an optimal balance between the pharmacological, biochemical and chemical aspects. Describing all facets of modem drug design and development, this major textbook will be an invaluable source of information for smdents of chemistry, pharmacology, pharmacy, medicinal chemistry, medicine and biochemistry from undergraduate to postdoctoral levels.
Starting with an overview of drug discovery the book follows drug design and development from the initial structure-activity relationship to the final processes of clinical evaluation and registration. A number of chapters look at the design of drugs for particular cellular targets such as ion channels and receptors whilst others... Tovább

Fülszöveg

A TEXTBOOK OF DRUG DESIGN AND DEVELOPMENT SECOND EDITION edited by
Povl Krogsgaard-Larsen, Tommy Liljefors and Ulf Madsen
The second edition of A Textbook of Drug Design and Development has been completely revised and updated. It covers the separate but interconnecting areas of chemistry and biology, maintaining an optimal balance between the pharmacological, biochemical and chemical aspects. Describing all facets of modem drug design and development, this major textbook will be an invaluable source of information for smdents of chemistry, pharmacology, pharmacy, medicinal chemistry, medicine and biochemistry from undergraduate to postdoctoral levels.
Starting with an overview of drug discovery the book follows drug design and development from the initial structure-activity relationship to the final processes of clinical evaluation and registration. A number of chapters look at the design of drugs for particular cellular targets such as ion channels and receptors whilst others examine specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research is covered as is the design and application of prodrugs to improve delivery. The important developing areas of modelling and combinatorial approaches are also included. ^
About the editors
Povl Krogsgaard-Larsen^ an editor of the first edition, is Professor of Medicinal Chemistry at the Royal Danish School of Pharmacy, Copenhagen, Denmark, from where he graduated and received his PhD and D.Sc. He has held the post of Visiting Scientist at the Australian National University, University of California and University of Kansas. He is a Trustee of the Alfred Benzon Foundation and a member of the Danish Academy of Sciences and the Board of Directors of the Carlsberg Foundation. He has received a number of prizes for his scientific endeavours, including most recently the PV Petersen Prize. His main research interest is in neurotransmitters and he has also carried out extensive work in heterocyclic chemistry.
Tommy Liljefors^is Research Professor in Computational Chemistry at the Royal Danish School of Pharmacy. He previously held a Senior Lectureship in Organic Chemistry at the University of Lund, from where he received his PhD. His main research interest is computer-aided molecular design and he is currently focussing on structure-activity relationships for neurotransmitter agonists and antagonists.
Ulf Madsen gained his PhD from the Royal Danish School of Pharmacy where he is currently Associate Professor of Medicinal Chemistry. He has been a visiting scientist at the University of Sydney, Australia; Johan Wolfgang Goethe University, Frankfurt, Germany and at Syntex Research in California. His main research interest is the molecular pharmacology of excitatory amino acid receptor agonists and antagonists.
Reviews of the First Edition
Excellent book .Excellent source material .The editors set a high standard.
Professor Graham Johnston writing in TiPS a good and substantial book good introductions to many aspects of a complex subject .a pleasing combination of traditional and mechanistic approaches.
Professor Chris Ramsden writing in Chemistry and Industry .an excellent introduction to drug design.
Professor TW Stone, University of Glasgow .a good illustration of structure-activity principles .the combination of organic chemistry, analytical chemistry, biology and pharmacology .is most relevant.
Professor Hanne HJorth T0nnesen, University of Oslo Vissza